Uses of Arbitan: - Hypertension (high blood pressure) Diabetic nephropathy, Hypertension Hypersensitivity; pregnancy and lactation.

How to use Hydrochlorothiazide + Irbesartan: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Hydrochlorothiazide + Irbesartan may be taken with or without food, but it is better to take it at a fixed time. Adult Dose: Hypertension 150 mg/12.5 mg PO qDay intially; if needed, after 1-2 weeks may titrate up to 300 mg/25 mg PO qDay

Other antihypertensives, lithium, K-sparing diuretics, K supplements, salt substitutes containing K. CNS depressants, antidiabetics, cholestyramine & colestipol resins, corticosteroids, ACTH, digitalis glycosides, antiarrhythmics, NSAIDs, tubocurarine, antigout medications, Ca salts. Alcohol; ?-blockers, diazoxide, atropine, beperiden, amantadine, cyclophosphamide, methotrexate.

Hypersensitivity; pregnancy and lactation.

Common - Nausea - Taste change - Upset stomach - Diarrhea - Weakness - Dizziness - Headache - Glucose intolerance - Increased blood uric acid - Increased blood lipid level - Electrolyte imbalance - Decreased blood pressure >10% Irbesartan Hyperkalemia (19%) 1-10% Chest pain (2%),Tachycardia (1%),Abnormal urination (2%),Musculoskeletal pain (6%),Flu-like syndrome (3%),Edema (3%),Tachycardia (1%),Chest pain (2%),Creatinine increased (1%),Increased BUN (2%) Irbesartan Dizziness (10%),URI (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%) Frequency Not Defined Hydrochlorothiazide Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia,Headache

Precaution: Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy. Lactation: discontinue drug or do not nurse

Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions. Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.

Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)