Uses of Alisken 150: - Hypertension (high blood pressure) Oral Essential hypertension Adult: >18 yr 150 mg once daily, increased to 300 mg once daily if needed. Elderly: No dosage adjustment needed. Hepatic impairment: No dosage adjustment needed.

How to use Aliskiren: Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aliskiren may be taken with or without food, but it is better to take it at a fixed time. Administration: Increased risk of hypotension w/ other antihypertensives. Increased risk of acute renal failure w/ ACE inhibitors, angiotensin II receptor antagonists or NSAIDs. Antihypertensive effect may be reduced w/ NSAIDs. Increased serum levels w/ atorvastatin, itraconazole, ketoconazole, verapamil. Significant decrease in furosemide concentrations w/ aliskiren. Increased risk of hyperkalaemia w/ potassium-sparing diuretics, potassium supplements or any substances that may increase serum potassium levels. Potentially Fatal: Increased risk of renal impairment, hypotension and hyperkalaemia w/ ACE inhibitors or angiotensin II receptor antagonists. Markedly increased plasma concentration w/ ciclosporin, itraconazole and quinidine. Adult Dose: Serious CHF, sodium or volume depletion. Discontinue if diarrhoea is severe and persistent. Lactation. Monitoring Parameters Periodically monitor serum potassium concentration and renal function. Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death. Lactation: Excretion in milk unknown/not recommended. Child Dose: C (1st trimester), D (2nd & 3rd trimesters) Renal Dose: Aliskiren is an orally active, potent, non-peptide and selective direct renin inhibitor used in the management of HTN. By inhibiting the enzyme renin, it prevents conversion of angiotensinogen into angiotensin I and therefore inhibits subsequent production of angiotensin II and aldosterone. Unlike ACE inhibitors and angiotensin II receptor antagonists which cause a compensatory rise in plasma renin activity, treatment w/ aliskiren decreases plasma renin activity and concentrations of angiotensin I, angiotensin II and aldosterone .

History of angioedema; severe renal impairment. Concomitant use w/ ACE inhibitors or angiotensin II receptor antagonists in patients w/ DM and renal impairment (GFR <60 mL/min). Concomitant use w/ ciclosporin, itraconazole and quinidine. Pregnancy.

Common - Diarrhea - Dizziness - Joint pain - Increased potassium level in blood Renal Impairment Mild to moderate: No dosage adjustment needed. Severe: Contraindicated.

Precaution: Hypertension

Administration May be taken with or without food. Take consistently w/ or w/o meals. Avoid taking w/ high fat meals.

1-10% Diarrhea (2.3%),Cough (1.1%),Rash (1%),Increase in serum creatinine (<7%),Hyperkalemia (<1%) <1% Angioedema,Headache,Gout,Renal stones,Seizure,Severe hypotension,Rhabomyolysis,Toxic epidermal necrolysis,Increase in uric acid,Angina Potentially Fatal: Anaphylactic reactions.