Aglip 25 mg
Alogliptin
Category: Tablet
Manufacturer: Eskayef Bangladesh Ltd.
Price: 440.0 ৳
20's Pack
10's Strip
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Aglip is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type-2 diabetes mellitus.
Aglip is primarily renally excreted. Cytochrome (CYP) P450-related metabolism is negligible. No significant drug-drug interactions are observed with the CYP-substrates or inhibitors tested or with renally excreted drugs.
History of a serious hypersensitivity reaction to Alogliptin-containing products, such as anaphylaxis, angioedema or severe cutaneous adverse reactions.
Common side effects are nasopharyngitis, headache and upper respiratory tract infection.
Acute pancreatitis: If pancreatitis is suspected, promptly Aglip should be discontinued.Hypersensitivity: There have been postmarketing reports of serious hypersensitivity reactions in patients treated with Aglip such as anaphylaxis, angioedema and severe cutaneous adverse reactions. In such cases, promptly Aglip should be discontinued.Hepatic effects: Postmarketing reports of hepatic failure, sometimes fatal. Causality can not be excluded. If liver injury is detected, promptly interrupt Aglip and assess patient for probable cause, then treat cause if possible, to resolution or stabilization. Do not restart Aglip if liver injury is confirmed and no alternative etiology can be found.Hypoglycemia: When an insulin secretagogue (e.g. sulfonylurea) or insulin is used in combination with Aglip, a lower dose of the insulin secretagogue or insulin may be required to minimize the risk of hypoglycaemia.Macrovascular outcomes: There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with Aglip or any other antidiabetic drug.
The highest doses of Aglip administered in clinical trials were single doses of 800 mg to healthy subjects and doses of 400 mg once daily for 14 days to patients with type 2 diabetes (equivalent to 32 times and 16 times the maximum recommended clinical dose of 25 mg, respectively). No serious adverse events were observed at these doses. In the event of an overdose, it is reasonable to institute the necessary clinical monitoring and supportive therapy as dictated by the patient's clinical status. Per clinical judgment, it may be reasonable to initiate removal of unabsorbed material from the gastrointestinal tract. Aglip is minimally dialyzable; over a 3-hour hemodialysis session, approximately 7% of the drug was removed. Therefore, hemodialysis is unlikely to be beneficial in an overdose situation. It is not known if Aglip is dialyzable by peritoneal dialysis.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Dipeptidyl Peptidase-4 (DPP-4) inhibitor
Alogliptin is a DPP-4 inhibitor that slows the inactivation of the incretin hormones, thereby increasing their bloodstream concentrations and reducing fasting and postprandial glucose concentrations in a glucose-dependent manner in patients with type 2 diabetes mellitus. Increased concentrations of the incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released into the bloodstream from the small intestine in response to meals. These hormones cause insulin release from the pancreatic beta cells in a glucose-dependent manner but are inactivated by the DPP-4 enzyme within minutes. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, reducing hepatic glucose production. In patients with type 2 diabetes, concentrations of GLP-1 are reduced but the insulin response to GLP-1 is preserved.
Pregnancy Category B. No adequate or well-controlled studies in pregnant women have been conducted with Alogliptin. Alogliptin tablets should be used during pregnancy only if clearly needed. It is not known whether Alogliptintin is excreted in human milk. caution should be exercised when Alogliptin is administered to a nursing woman.
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